CAVER - software tool for protein analysis and visualisation

CAVER is a software tool for analysis and visualisation of tunnels and channels in protein structures. Tunnels are void pathways leading from a cavity buried in a protein core to the surrounding solvent. Unlike tunnels, channels lead through the protein structure and their both endings are opened to the surrounding solvent. Studying of these pathways is highly important for drug design and molecular enzymology.

CAVER provides rapid, accurate and fully automated calculation of tunnels and channels in static structures. The molecules amendable to analysis of CAVER include proteins, nucleic acids or inorganic materials.

CAVER can be used either as PyMol plugin or independent application CAVER Viewer. CAVER Viewer has been designed for easy set-up of calculation, visualization of results and efficient data analysis. CAVER Viewer runs online using the Java Web Start technology.

Currently the latest CAVER 3.0 command-line version performing the analysis of dynamic molecular simulations is available.