CAVER is a software tool for analysis and visualization of tunnels and channels in protein structures. Tunnels are void pathways leading from a cavity buried in a protein core to the surrounding solvent. Unlike tunnels, channels lead through the protein structure and their both endings are opened to the surrounding solvent. Studying of these pathways is highly important for drug design and molecular enzymology.

CAVER Analyst

CAVER provides rapid, accurate and fully automated calculation of tunnels and channels in static and dynamic structures. The molecules amendable to analysis of CAVER include proteins, nucleic acids, or inorganic materials.

The software is available as CAVER 3.0 command-line version, CAVER 3.0 PyMol plugin or graphical application CAVER Analyst 1.0. The latest version of CAVER enables the analysis of molecular dynamics simulations. CAVER Analyst allows easy set-up of calculation, visualization of results, and efficient visual analysis of data.

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1219 citations
6293 registered users
111840x CAVER downloaded


March 12, 2023

CAVER was recently cited by a NATURE paper entitled Structural basis for bacterial energy extraction...

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CAVER was recently cited by an article entitled Cryo-EM structure of human heptameric pannexin 2...

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February 28, 2023

CAVER was recently cited by NATURE Communications in the article entitled Enzyme adaptation to...

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